A Nexus model of cellular transition in cancer

Biological research: BR

Payal Chatterjee¹  Mukesh Yadav² 

[1]Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, USA

[2]Department of Pharmaceutical Sciences, Softvision College and Research Institute, Indore, India

关键词: Cancer;    The Nexus model;    Biochemical stress;    Epigenetics;    Mutations;    Genetics;   

DOI  :  10.1186/s40659-018-0173-8

学科分类：生物科学（综合）

来源: BioMed Central

【 摘 要 】

The exact cause of cancer is one of the most immutable medical questions of the century. Cancer as an evolutionary disease must have a purpose and understanding the purpose is more important than decoding the cause. The model of cancer proposed herein, provides a link between the cellular biochemistry and cellular genetics of cancer evolution. We thus call this model as the “Nexus model” of cancer. The Nexus model is an effort to identify the most apparent route to the disease. We have tried to utilize existing cancer literature to identify the most plausible causes of cellular transition in cancer, where the primary cancer-causing agents (physical, chemical or biological) act as inducing factors to produce cellular impeders. These cellular impeders are further linked to the Nexus. The Nexus then generates codes for epigenetics and genetics in cancer development.

【 授权许可】

CC BY