Distinct fermentation and antibiotic sensitivity profiles exist in salmonellae of canine and human origin

BMC Microbiology

Preena Lowden¹  Corrin V. Wallis² 

[1] Life and Health Sciences, Aston University, Birmingham, UK;The WALTHAM Centre for Pet Nutrition, Melton Mowbray, Leicestershire, UK

关键词: S. Enterica;    Serovar;    Dog;    Zoonosis;    Anthroponosis;    Biolog;    MIC;   

DOI  :  10.1186/s12866-018-1153-4

学科分类：微生物学和免疫学

来源: BioMed Central

【 摘 要 】

Salmonella enterica is a recognised cause of diarrhoea in dogs and humans, yet the potential for transfer of salmonellosis between dogs and their owners is unclear, with reported evidence both for and against Salmonella as a zoonotic pathogen. A collection of 174 S. enterica isolates from clinical infections in humans and dogs were analysed for serotype distribution, carbon source utilisation, chemical and antimicrobial sensitivity profiles. The aim of the study was to understand the degree of conservation in phenotypic characteristics of isolates across host species. Serovar distribution across human and canine isolates demonstrated nine serovars common to both host species, 24 serovars present in only the canine collection and 39 solely represented within the human collection. Significant differences in carbon source utilisation profiles and ampicillin, amoxicillin and chloramphenicol sensitivity profiles were detected in isolates of human and canine origin. Differences between the human and canine Salmonella collections were suggestive of evolutionary separation, with canine isolates better able to utilise several simple sugars than their human counterparts. Generally higher minimum inhibitory concentrations of three broad-spectrum antimicrobials, commonly used in veterinary medicine, were also observed in canine S. enterica isolates. Differential carbon source utilisation and antimicrobial sensitivity profiles in pathogenic Salmonella isolated from humans and dogs are suggestive of distinct reservoirs of infection for these hosts. Although these findings do not preclude zoonotic or anthroponotic potential in salmonellae, the separation of carbon utilisation and antibiotic profiles with isolate source is indicative that infectious isolates are not part of a common reservoir shared frequently between these host species.

【 授权许可】

CC BY