Human ocular filariasis: further evidence on the zoonotic role of Onchocerca lupi

Particle and Fibre Toxicology

Odile Bain²  Yasen Mutafchiev¹  Trimèche Mounir³  Andrea Gustinelli⁴  Ozden Buyukbaba Boral⁷  Nesimi Buyukbabani⁸  Baris Yeniad⁵  Zafer Cebeci⁵  Filipe Dantas-Torres⁹  Domenico Otranto⁶ 

[1] Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Sofia, Bulgaria;Muséum National d’Histoire Naturelle, UMR 7205 CNRS, Parasitologie Comparée, Paris, France;Laboratoire d’Anatomie et de Cytologie Pathologiques, CHU Farhat Hasched, Sousse, Tunisia;Dipartimento di Sanità Pubblica e Patologia Animale, Università degli Studi di Bologna, Ozzano Emilia, Bologna, Italy;Department of Ophtalmology, Istanbul University Faculty of Medicine, Istanbul, Turkey;Dipartimento di Sanità Pubblica Veterinaria e Zootecnia, Università degli Studi di Bari, Bari, Valenzano, Italy;Department of Clinical Microbiology, Istanbul University Faculty of Medicine, Istanbul, Turkey;Department of Pathology, Istanbul University Faculty of Medicine, Istanbul, Turkey;Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães (Fiocruz-PE), Pernambuco, Recife, Brazil

关键词: Turkey, Tunisia;    Dog;    Ocular infestation;    Zoonosis;    Onchocerca lupi;   

Others  :  1232473
DOI  :  10.1186/1756-3305-5-84

 received in 2012-04-08, accepted in 2012-04-27,  发布年份 2012

【 摘 要 】

Background

Among ocular vector-borne pathogens, Onchocerca volvulus, the agent of the so-called “river blindness”, affects about 37 million people globally. Other Onchocerca spp. have been sporadically reported as zoonotic agents. Cases of canine onchocerciasis caused by Onchocerca lupi are on the rise in the United States and Europe. Its zoonotic role has been suspected but only recently ascertained in a single case from Turkey. The present study provides further evidence on the occurrence of O. lupi infesting human eyes in two patients from Turkey (case 1) and Tunisia (case 2). The importance of obtaining a correct sample collection and preparation of nematodes infesting human eyes is highlighted.

Methods

In both cases the parasites were identified with morpho-anatomical characters at the gross examination, histological analysis and anatomical description and also molecularly in case 1.

Results

The nematode from the first case was obviously O. lupi based on their morphology at the gross examination, histological analysis and anatomical description. In the second case, although the diagnostic cuticular characters were not completely developed, other features were congruent with the identification of O. lupi. Furthermore, the morphological identification was also molecularly confirmed in the Turkish case.

Conclusions

The results of this study suggest that O. lupi infestation is not an occasional finding but it should be considered in the differential diagnosis of other zoonotic helminths causing eye infestation in humans (e.g., D. immitis and Dirofilaria repens). Both cases came from areas where no cases of canine onchocerciasis were previously reported in the literature, suggesting that an in depth appraisal of the infestation in canine populations is necessary. Physicians and ophthalmologists are advised on how to preserve nematode samples recovered surgically, to allow a definitive, correct etiological diagnosis.

【 授权许可】

   
2012 Dantas-Torres et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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