Lipid metabolism and carcinogenesis, cancer development

American Journal of Cancer Research

Ke Du¹  Neng Zhu²  Yu-Fang Yin³  Jia Long⁴  Chan-Juan Zhang⁵ 

[1] Department of Biochemistry Molecular Biology, University of Calgary, Calgary, Alberta, Canada;Department of Neuroscience and Pharmacology, School of Medicine, Southern Illinois University, Springfield, Illinois, United States;Division of Stem Cell Regulation and Application, Key Lab for Quality Evaluation of Bulk Herbs of Hunan Province, Hunan University of Chinese Medicine, Changsha, Hunan Province, China;School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, China;The First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha, Hunan, China

关键词: Lipid;    lipid metabolism;    carcinogenesis;    cancer development;    cancer treatment;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

The disorder of lipid metabolism is pathologically linked to hyperlipidemia, lipid storage disease, obesity and other related diseases. Intriguingly, recent studies have revealed that lipid metabolism disorders play an important role in carcinogenesis and development as well, since they cause abnormal expression of various genes, proteins, and dysregulation of cytokines and signaling pathways. More importantly, lipid-lowering drugs and anti-lipid per-oxidation treatment have been showing their advantages in clinic, in comparison with other anti-cancer drugs with high toxicity. Thus, further elucidation of molecular mechanism between lipid metabolism and cancer is essential in developing novel diagnostic biomarkers and therapeutic targets of human cancers.

【 授权许可】

CC BY-NC