Effect of Gemcitabine on HOTAIR Expression Level in H596 and H1944 Cell Lines

Proceedings

Domaniku, Aylin¹  Kandemiş, Emine²  Polat, Ä°rem³ 

[1] Authors to whom correspondence should be addressed.;Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Bahçeşehir University, 34353 Istanbul, Turkey;Presented at the 2nd International Cell Death Research Congress, Izmir, Turkey, 1–4 November 2018

关键词: lung cancer;    lncRNA;    HOTAIR;    Gemcitabine;   

DOI  :  10.3390/proceedings2251590

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Genetic alterations affect carcinogenesis, and recent studies demonstrated that long non-coding RNAs (lncRNAs) have critical roles during this process. Hox transcript antisense intergenic RNA (HOTAIR) is a lncRNA molecule that affects proliferation, survival, migration, genomic stability, and drug resistance of cancer cells. The purpose of this study is to examine the possible effects of Gemcitabine treatment on HOTAIR expression level in non-small cell lung cancer (NSCLC) cell lines, H1944 and H596.

【 授权许可】

CC BY