Long Non-Coding RNAs in Obesity-Induced Cancer

Non-Coding RNA

Chi-Ming Wong¹  Chien-Ling Huang¹  Lu Xu²  MabelYin-Chun Yau³ 

[1] Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China;Department of Medicine, The University of Hong Kong, Hong Kong, China;School of Medical and Health Sciences, Tung Wah College, Hong Kong, China;

关键词: obesity;    cancer;    lncRNA;    ANRIL;    H19;    HOTAIR;   

DOI  :  10.3390/ncrna4030019

来源: DOAJ

【 摘 要 】

Many mechanisms of obesity-induced cancers have been proposed. However, it remains unclear whether or not long non-coding RNAs (lncRNAs) play any role in obesity-induced cancers. In this article, we briefly discuss the generally accepted hypotheses explaining the mechanisms of obesity-induced cancers, summarize the latest evidence for the expression of a number of well-known cancer-associated lncRNAs in obese subjects, and propose the potential contribution of lncRNAs to obesity-induced cancers. We hope this review can serve as an inspiration to scientists to further explore the regulatory roles of lncRNAs in the development of obesity-induced cancers. Those findings will be fundamental in the development of effective therapeutics or interventions to combat this life-threatening adverse effect of obesity.

【 授权许可】

Unknown