The association between birth weight and the risk of type 2 diabetes mellitus: a systematic review and meta-analysis

Endocrine journal

Yunjia Zhang¹  An Song²  Hang Zhao³ 

[1] Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China;Endocrinology Department, Hebei General Hospital, Shijiazhuang, 050051, China;Graduate School of Hebei Medical University, Shijiazhuang, 050017, China

关键词: Diabetes mellitus;    Type 2;    Birth weight;    Meta-analysis;   

DOI  :  10.1507/endocrj.EJ18-0072

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

Previous studies have shown a relationship between type 2 diabetes mellitus and birth weight. We performed this meta-analysis to resolve the problem of inconsistent results. We conducted a literature search of PubMed, Embase and the Cochrane Library using “Diabetes Mellitus, Type 2,” “Birth Weight,” and some related free words. Twenty-one studies were included in accordance with inclusion and exclusion criteria, involving a total of 313,165 participants and 22,341 type 2 diabetes mellitus cases. A modified version of the Newcastle-Ottawa Scale was used to evaluate the methodological quality of studies included. We used Review Manager 5.3 for data merging and statistical analysis. Results were expressed as odds ratio (OR) and 95% confidence interval (95% CI). The risk of diabetes with low birth weight (<2,500 g) was higher than that with birth weight ≥2,500 g, (OR = 1.51, 95% CI: 1.43, 1.58). Compared with normal birth weight (2,500–4,000 g), low birth weight, but not high birth weight, increased the risk of diabetes (OR = 1.41, 95% CI: 1.26, 1.58). There is a negative association between birth weight and the future risk of type 2 diabetes mellitus.

【 授权许可】

Unknown