A network map of IL-33 signaling pathway

Journal of Cell Communication and Signaling

D. A. B. Rex¹  Sneha M. Pinto²  Rajesh Raju³  Yashwanth Subbannayya⁴ 

[1] Computational Biology Group, Cancer Research Program, Rajiv Gandhi Centre for Biotechnology;International Technology Park;Manipal Academy of Higher Education (MAHE);Yenepoya (Deemed to be University)

关键词: Immune response;    Inflammation;    NetSlim;    Pro-inflammatory cytokine;    Post-translational modifications;    Protein-protein interactions;   

DOI  :  10.1007/s12079-018-0464-4

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central role in the regulation of immune responses. Its release from epithelial and endothelial cells is mediated by pro-inflammatory cytokines, cell damage and by recognition of pathogen-associated molecular patterns (PAMPs). The activity of IL-33 is mediated by binding to the IL-33 receptor complex (IL-33R) and activation of NF-κB signaling via the classical MyD88/IRAK/TRAF6 module. IL-33 also induces the phosphorylation and activation of ERK1/2, JNK, p38 and PI3K/AKT signaling modules resulting in the production and release of pro-inflammatory cytokines. Aberrant signaling by IL-33 has been implicated in the pathogenesis of several acute and chronic inflammatory diseases, including asthma, atopic dermatitis, rheumatoid arthritis and ulcerative colitis among others. Considering the biomedical importance of IL-33, we developed a pathway resource of signaling events mediated by IL-33/IL-33R in this study. Using data mined from the published literature, we describe an integrated pathway reaction map of IL-33/IL-33R consisting of 681 proteins and 765 reactions. These include information pertaining to 19 physical interaction events, 740 enzyme catalysis events, 6 protein translocation events, 4 activation/inhibition events, 9 transcriptional regulators and 2492 gene regulation events. The pathway map is publicly available through NetPath (http://www.netpath.org/), a resource of human signaling pathways developed previously by our group. This resource will provide a platform to the scientific community in facilitating identification of novel therapeutic targets for diseases associated with dysregulated IL-33 signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_120.

【 授权许可】

CC BY