Early perfusion and dopamine transporter imaging using 18F-FP-CIT PET/CT in patients with parkinsonism

American Journal of Nuclear Medicine and Molecular Imaging

Ho-Sung Ryu¹  Chae-Moon Hong³  Byeong-Cheol Ahn⁴ 

[1] Department of Neurology, Kyungpook National University Hospital, Daegu, Republic of Korea;Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea;Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea;Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

关键词: FP-CIT;    PET;    dual-phase;    perfusion;    dopamine transporter;    FDG;    parkinsonism;    parkinson plus syndrome;   

DOI  :  

学科分类：过敏症与临床免疫学

来源: e-Century Publishing Corporation

【 摘 要 】

Combined use of 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) for dopamine transporter imaging and 18F-fludeoxyglucose (FDG) for glucose metabolism shows good diagnostic performance for differential diagnosis of Parkinson disease (PD) and Parkinson plus syndrome (multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies). A recent study showed that 18F-FP-CIT positron emission tomography (PET) with early perfusion imaging is useful for the differential diagnosis of PD and Parkinson plus syndrome with lower radiation exposure, time, and cost. In this review, we summarize the advantages of using 18F-FP-CIT PET for perfusion and dopamine transporter imaging, as well as clinical features useful for the differential diagnosis of PD and Parkinson plus syndrome.

【 授权许可】

CC BY-NC