American Journal of Cancer Research | |
miR-203a-3p promotes colorectal cancer proliferation and migration by targeting PDE4D | |
Huabin Gao1  Lin Chen2  | |
[1] Department of Oncology, Shenzhen Hospital of Southern Medical University, Shenzhen, China;Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China | |
关键词: Colorectal cancer; micro-RNA; miR-203a-3p; PDE4D; | |
DOI : | |
学科分类:肿瘤学 | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. microRNA has been reported playing an important role in a variety of cancers including colorectal cancer. miR-203a-3p has been found up-regulated in CRC tissues compare with the adjacent normal tissues. But, how miR-203a-3p regulates CRC development remains to be elucidated. In this study, gain and loss-of-function assays showed that miR-203a-3p promotes colorectal cancer cell proliferation, colony formation and migration and invasion by targeting PDE4D. And miR-203a-3p/β-catenin/Cyclin D1/c-Myc signaling pathway is involved in the CRC. In summary, this study highlights an onco-miRNA role for miR-203a-3p by regulating PDE4D in CRC and suggests that miR-203a-3p may be a novel molecular therapeutic target for CRC.
【 授权许可】
CC BY-NC
【 预 览 】
Files | Size | Format | View |
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RO201910251738899ZK.pdf | 6381KB | download |