Regulation and phylogeny of skeletal muscle regeneration

Developmental biology

Shahragim Tajbakhsh^1,2¹  Meryem B. Baghdadi^1,2,3³ 

[1] CNRS UMR 3738, Institut Pasteur, Paris 75015, France^2;Sorbonne Universités, UPMC, University of Paris 06, IFD-ED 515, 4 Place Jussieu, Paris 75252, France^3;Stem Cells and Development, CNRS URA 3738, Department of Developmental&Stem Cell Biology, Institut Pasteur, 25 rue du Dr. Roux, 75015 Paris, France^1

关键词: Skeletal muscle;    Regeneration;    Stem cells;    Evolution;    Quiescence;    Injury;   

DOI  :  10.1016/j.ydbio.2017.07.026

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

One of the most fascinating questions in regenerative biology is why some animals can regenerate injured structures while others cannot. Skeletal muscle has a remarkable capacity to regenerate even after repeated traumas, yet limited information is available on muscle repair mechanisms and how they have evolved. For decades, the main focus in the study of muscle regeneration was on muscle stem cells, however, their interaction with their progeny and stromal cells is only starting to emerge, and this is crucial for successful repair and re-establishment of homeostasis after injury. In addition, numerous murine injury models are used to investigate the regeneration process, and some can lead to discrepancies in observed phenotypes. This review addresses these issues and provides an overview of some of the main regulatory cellular and molecular players involved in skeletal muscle repair.

【 授权许可】

CC BY