Evolutionary analysis of nucleosome positioning sequences based on New Symmetric Relative Entropy

Genomics

Hu Meng^1¹ 

[1] Laboratory of Theoretical Biophysics, School of Physical Science and Technology, Inner Mongolia University, Hohhot 010021, China^1

关键词: TSS;    Transcription Start Site;    SRE;    Symmetric Relative Entropy;    NSRE;    New Symmetric Relative Entropy;    Ac-NSRE;    Accumulated New Symmetric Relative Entropy;    Nucleosome sequence;    Concerted evolution;    Transcription regulation;    Sequence preference;    Constitutive property;   

DOI  :  10.1016/j.ygeno.2017.09.007

学科分类：医学（综合）

来源: Academic Press

【 摘 要 】

New Symmetric Relative Entropy (NSRE) was applied innovatively to analyze the nucleosome sequences in S. cerevisiae, S. pombe and Drosophila. NSRE distributions could well reflect the characteristic differences of nucleosome sequences among three organisms, and the differences indicate a concerted evolution in the sequence usage of nucleosome. Further analysis about the nucleosomes around TSS shows that the constitutive property of + 1/− 1 nucleosomes in S. cerevisiae is different from that in S. pombe and Drosophila, which indicates that S. cerevisiae has a different transcription regulation mechanism based on nucleosome. However, in either case, the nucleosome dyad region is conserved and always has a higher NSRE. Base composition analysis shows that this conservative property in nucleosome dyad region is mainly determined by base A and T, and the dependence degrees on base A and T are consistent in three organisms.

【 授权许可】

CC BY