The phenotypic and functional properties of mouse yolk-sac-derived embryonic macrophages

Developmental biology

June-Hee Park^5¹  Ross A. Poché^1²  Nejla Yosef^1³  Tegy J. Vadakkan^1⁴  Jean-Leon Thomas^5,6⁵  Mary E. Dickinson^1,2,3,4⁶ 

[1] Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA^3;Department of Bioengineering, Rice University, Houston, TX, USA^4;Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA^1;Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA^2;Department of Neurology, Yale University, New Haven, CT, USA^5;Sorbonne Universités UPMC Univ Paris 06, Inserm, CNRS, APHP, Institut du Cerveau et de la Moelle épinière (ICM), GH Pitié-Salpêtrière, Paris, France^6

关键词: Yolk sac;    Macrophages;    Microglia;    Angiogenesis;    Endothelial Cells;    Neural Stem/Progenitor Cells;   

DOI  :  10.1016/j.ydbio.2018.07.009

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Macrophages are well characterized as immune cells. However, in recent years, a multitude of non-immune functions have emerged many of which play essential roles in a variety of developmental processes (Wynn et al., 2013; DeFalco et al., 2014). In adult animals, macrophages are derived from circulating monocytes originating in the bone marrow, but much of the tissue-resident population arise from erythro-myeloid progenitors (EMPs) in the extra-embryonic yolk sac, appearing around the same time as primitive erythroblasts (Schulz et al., 2012; Kierdorf et al., 2013; McGrath et al., 2015; Gomez Perdiguero et al., 2015; Mass et al., 2016). Of particular interest to our group, macrophages have been shown to act as pro-angiogenic regulators during development (Wynn et al., 2013; DeFalco et al., 2014, Hsu et al., 2015), but there is still much to learn about these early cells.

【 授权许可】

CC BY