Molecular mechanisms of glucose uptake in skeletal muscle at rest and in response to exercise

Motriz. Revista de Educacao Fisica

Ropelle, Eduardo Rochete¹  Moura, Leandro Pereira de¹  Muñoz, Vitor Rosetto²  Gaspar, Rodrigo Stellzer²  Pauli, José Rodrigo²  Pereira, Rodrigo Martins²  Silva, Adelino Sanchez Ramos da³ 

[1] Universidade Estadual de Campinas, Campinas, Brazil;Universidade Estadual de Campinas, Limeira, Brazil;Universidade de São Paulo, Ribeirão Preto, Brazil

关键词: exercise;    skeletal muscle;    glucose uptake;    GLUT4.;   

DOI  :  10.1590/s1980-6574201700si0004

学科分类：社会科学、人文和艺术（综合）

来源: Universidade Estadual Paulista "Julio de Mesquita Filho" * Departamento de Educacao Fisica

【 摘 要 】

Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated.

【 授权许可】

CC BY