| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Foxp3‐mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells | |
| 关键词: signal transduction; metabolism; lymphocyte; autoimmunity; | |
| DOI : 10.1189/jlb.2AB0514-273RR | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
CD4+CD25+Foxp3+TregshaveadiminishedcapacitytoactivatethePI3K/Aktpathway.AlthoughbluntedAktactivityisnecessarytomaintainTregfunction,theconsequencesofthisalteredsignalingareunclear.Glut1isacell‐surfacereceptorresponsibleforfacilitatingglucosetransportacrossplasmamembranes,whoseexpressionistightlycoupledtocostimulatorysignalsandAktphosphorylation.FreshlyisolatedhumanTregswereunabletoup‐regulateGlut1inresponsetoTCRandcostimulatorysignalscomparedwithTconv.Consequently,theabilityofTregstouseglucosewasalsoreduced.IntroductionofFoxp3intoTconvinhibitedAktactivationandGlut1expression,indicatingthatFoxp3canregulateGlut1.Finally,pharmacologicactivationofAktinTregscaninduceGlut1,overcomingtheeffectsofFoxp3.Together,theseresultsillustratethemolecularbasisbehinddifferentialglucosemetabolisminTregs...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904049906830ZK.pdf | 909KB |  download |
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