| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Profound loss of intestinal Tregs in acutely SIV‐infected neonatal macaques | |
| 关键词: infant; CD25; FoxP3; intestine; | |
| DOI : 10.1189/jlb.4A0514-266RR | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
ImpairmentoftheintestinalmucosalimmunesystemisanearlyfeatureofHIV‐infectedchildren.Mostinfectedchildrenexhibitclinicalgastrointestinalsymptomsatsomestageofinfection,andpersistentdiarrheaisamarkerforrapiddiseaseprogression.ItisknownthatTregsareespeciallyimportantinmediatingintestinalimmunehomeostasisandthatlossofthissubsetmayresultinintestinalinflammationandassociatedclinicalsigns.LargenumbersofFoxP3+Tcellswerefoundinalltissuesinnewbornmacaques,whichcoexpressedhighlevelsofCD25andCD4,indicatingthattheywereTregs.Moreover,neonateshadmuchgreaterpercentagesofTregsinintestinaltissuescomparedwithperipherallymphoidtissues.AfterSIVinfection,asignificantlossofTregswasdetectedintheintestinecomparedwithage‐matchednormalinfants.Finally,SIV‐infectedFoxP3+Tcellsweredetectedintissuesinneonatesasearlyas7SIVdpi.TheseresultsdemonstratethatTregsconstituteasignificantfractionofCD4+Tcellsinneonatalintestinaltissuesandthatanearly,profoundlossofTregsoccursinacuteSIVinfection,whichmaycontributetotheintestinaldisordersassociatedwithneonatalHIVinfection...
【 授权许可】
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【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904049649388ZK.pdf | 2454KB |  download |
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