Profound loss of intestinal Tregs in acutely SIV‐infected neonatal macaques

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: infant;    CD25;    FoxP3;    intestine;   

DOI  :  10.1189/jlb.4A0514-266RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

ImpairmentoftheintestinalmucosalimmunesystemisanearlyfeatureofHIV‐infectedchildren.Mostinfectedchildrenexhibitclinicalgastrointestinalsymptomsatsomestageofinfection,andpersistentdiarrheaisamarkerforrapiddiseaseprogression.ItisknownthatTregsareespeciallyimportantinmediatingintestinalimmunehomeostasisandthatlossofthissubsetmayresultinintestinalinflammationandassociatedclinicalsigns.LargenumbersofFoxP3+Tcellswerefoundinalltissuesinnewbornmacaques,whichcoexpressedhighlevelsofCD25andCD4,indicatingthattheywereTregs.Moreover,neonateshadmuchgreaterpercentagesofTregsinintestinaltissuescomparedwithperipherallymphoidtissues.AfterSIVinfection,asignificantlossofTregswasdetectedintheintestinecomparedwithage‐matchednormalinfants.Finally,SIV‐infectedFoxP3+Tcellsweredetectedintissuesinneonatesasearlyas7SIVdpi.TheseresultsdemonstratethatTregsconstituteasignificantfractionofCD4+Tcellsinneonatalintestinaltissuesandthatanearly,profoundlossofTregsoccursinacuteSIVinfection,whichmaycontributetotheintestinaldisordersassociatedwithneonatalHIVinfection...

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