The Role of Congestion in Cardiorenal Syndrome Type 2: New Pathophysiological Insights into an Experimental Model of Heart Failure

Cardiorenal medicine

Annalisa Angelini ; Chiara Castellani ; Grazia Maria Virzì ; Marny Fedrigo ; Gaetano Thiene ; Marialuisa Valente ; Claudio Ronco ; Giorgio Vescovo

关键词: Matrix metallopeptidase 9;    Cardiorenal syndromes;    Neutrophil gelatinase-associated lipocalin;    Heart failure;    Cytokines;    Kidney injury;   

DOI  :  10.1159/000440775

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Background: In cardiorenal syndrome type 2 (CRS2), the role of systemic congestion in heart failure (HF) is still obscure. We studied a model of CRS2 [monocrotaline (MCT)-treated rats] secondary to pulmonary hypertension and right ventricular (RV) failure in order to evaluate the contribution of prevalent congestion to the development of kidney injury. Methods: Ten animals were treated with MCT for 4 weeks until they developed HF. Eleven animals were taken as controls. Signs of hypertro.

【 授权许可】

CC BY