| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| The myosin family: unconventional roles of actin‐dependent molecular motors in immune cells | |
| 关键词: cytoskeleton; cell motility; vesicular traffic; immune synapse; | |
| DOI : 10.1189/jlb.0711335 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
MyosinscompriseafamilyofATP‐dependentmotorproteinsthatarebestknownfortheirroleinmusclecontractionandtheirinvolvementinawiderangeofothereukaryoticmotilityprocesses.Recentphylogeneticanalysisplacesmyosinsinto35highlydiverseclasses.Althoughtheseactin‐basedmolecularmotorshavebeencharacterizedextensively,andmuchisknownabouttheirfunctionindifferentcellularcompartments,thereislittleinformationavailableaboutthesemoleculesinhematopoieticcells.Theavailabledataestablishthatmyosinsexpressedbyimmunecellsareabletosupportgeneraltasks,suchasmaintainingplasmamembranetension,movingandsecretingvesicles,aidinginendo‐andexocytoticprocesses,andpromotingtheadhesionandmotilityofcells.Additionally,however,myosinsareinvolvedinhighlyspecializedfunctions,suchasregulatingcellactivation,IS‐inducedsignaling,andtheseveringofmicrofilamentsviathecontrolofGTPases.Inthisreview,wesummarizethecurrentunderstandingofmyosinsinleukocytes,withemphasisontheemergingrolesofthesemolecularmotorsinimmunefunctions...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904048470342ZK.pdf | 1091KB |  download |
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