期刊论文详细信息
Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society
The myosin family: unconventional roles of actin‐dependent molecular motors in immune cells
关键词: cytoskeleton;    cell motility;    vesicular traffic;    immune synapse;   
DOI  :  10.1189/jlb.0711335
学科分类:生理学
来源: Federation of American Societies for Experimental Biology
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【 摘 要 】

MyosinscompriseafamilyofATP‐dependentmotorproteinsthatarebestknownfortheirroleinmusclecontractionandtheirinvolvementinawiderangeofothereukaryoticmotilityprocesses.Recentphylogeneticanalysisplacesmyosinsinto35highlydiverseclasses.Althoughtheseactin‐basedmolecularmotorshavebeencharacterizedextensively,andmuchisknownabouttheirfunctionindifferentcellularcompartments,thereislittleinformationavailableaboutthesemoleculesinhematopoieticcells.Theavailabledataestablishthatmyosinsexpressedbyimmunecellsareabletosupportgeneraltasks,suchasmaintainingplasmamembranetension,movingandsecretingvesicles,aidinginendo‐andexocytoticprocesses,andpromotingtheadhesionandmotilityofcells.Additionally,however,myosinsareinvolvedinhighlyspecializedfunctions,suchasregulatingcellactivation,IS‐inducedsignaling,andtheseveringofmicrofilamentsviathecontrolofGTPases.Inthisreview,wesummarizethecurrentunderstandingofmyosinsinleukocytes,withemphasisontheemergingrolesofthesemolecularmotorsinimmunefunctions...

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