WIP: more than a WASp‐interacting protein

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: cytoskeleton;    actin polymerization;    immune cells;    immune synapse;    lymphocytes;   

DOI  :  10.1189/jlb.2RU0314-162R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

WIPplaysanimportantroleintheremodelingoftheactincytoskeleton,whichcontrolscellularactivation,proliferation,andfunction.WIPregulatesactinpolymerizationbylinkingtheactinmachinerytosignalingcascades.WIPbindingtoWASpandtoitshomolog,N‐WASp,whicharecentralactivatorsoftheactin‐nucleatingcomplexArp2/3,regulatestheircellulardistribution,function,andstability.BybindingtoWASp,WIPprotectsitfromdegradationandthus,iscrucialforWASpretention.Indeed,mostmutationsthatresultinWAS,anX‐linkedimmunodeficiencycausedbydefective/absentWASpactivity,arelocatedintheWIP‐bindingregionofWASp.Inaddition,bybindingdirectlytoactin,WIPpromotestheformationandstabilizationofactinfilaments.WASp‐independentactivitiesofWIPconstituteanewresearchfrontierandarediscussedextensivelyinthisarticle.Here,wereviewthecurrentinformationonWIPinhumanandmousesystems,focusingonitsassociatedproteins,itsmolecular‐regulatorymechanisms,anditsroleasakeyregulatorofactin‐basedprocessesintheimmunesystem...

【 授权许可】

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