Cardiorenal Syndrome Type 1: Activation of Dual Apoptotic Pathways

Cardiorenal medicine

Silvia Pastori ; Grazia Maria Virzì ; Alessandra Brocca ; Massimo de Cal ; Vincenzo Cantaluppi ; Chiara Castellani ; Marny Fedrigo ; Gaetano Thiene ; Maria Luisa Valente ; Annalisa Angelini ; Giorgio Vescovo ; Claudio Ronco

关键词: Cardiorenal syndromes;    Caspase;    Acute kidney injury;    Apoptosis;    Renal tubular cells;   

DOI  :  10.1159/000438831

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Cardiorenal syndrome type 1 (CRS1) pathophysiology is complex, and immune-mediated damage, including alterations in the immune response with monocyte apoptosis and cytokine release, has been reported as a potential mechanism. In this study, we examined the putative role of renal tubular epithelial cell (RTC) apoptosis as a pathogenic mechanism in CRS1. In particular, we investigated the caspase pathways involved in induced apoptosis. We enrolled 29 patients with acute heart failure (AHF.

【 授权许可】

CC BY