Fueling the flame: bioenergy couples metabolism and inflammation

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: AMP;    epigenetics;    fatty acid oxidation;    glycolysis;    HIF‐;    1α;    NAD+ ;    Nampt;    obesity;    PGC‐;    1;    sepsis;   

DOI  :  10.1189/jlb.0212078

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Wereviewtheemergingconceptthatchangesincellularbioenergeticsconcomitantlyreprograminflammatoryandmetabolicresponses.Themolecularpathwaysofthisintegrativeprocessmodifyinnateandadaptiveimmunereactionsassociatedwithinflammation,aswellasinfluencingthephysiologyofadjacenttissueandorgans.Theinitiatingproinflammatoryphaseofinflammationisanabolicandrequiresglucoseastheprimaryfuel,whereastheopposingadaptationphaseiscatabolicandrequiresfattyacidoxidation.ThefuelswitchtofattyacidoxidationdependsonthesensingofAMPandNAD+byAMPKandtheSirTfamilyofdeacetylases(e.g.,SirT1,‐6,and‐3),respectively,whichcoupleinflammationandmetabolismbychromatinandproteinreprogramming.TheAMP‐AMPK/NAD+‐SirTaxisproceedssequentiallyduringacutesystemicinflammationassociatedwithsepsisbutceasesduringchronicinflammationassociatedwithdiabetes,obesity,andatherosclerosis.Rebalancingbioenergeticsresolvesinflammation.Manipulatingcellularbioenergeticsisidentifyingnewwaystotreatinflammatoryandimmunediseases...

【 授权许可】

CC BY