Alveolar macrophages in diabetes: friends or foes?

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: insulin;    diabetes mellitus;    innate immunity;    adaptive immunity;    phagocytosis;    cytokines;    macrophage polarization;    M1;    M2;   

DOI  :  10.1189/jlb.0911488

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

AMsconstituteanimportantbridgebetweeninnateandadaptiveimmunity.AMspatrolthelungsagainstpathogens,removesenescentcells,andhelprepairtissue.AMfunctionisalteredinmanydiseases,includingDM,whereAMabnormalimmuneresponsesmayworseninfectionsorleadtoexacerbationofinflammatoryreactions.InvivoexperimentalmodelshavegreatlycontributedtoourknowledgeofAMfunction.Studieshaveshownthatduringhyperglycemicstates,thephagocyticfunctionofAMsandtheexpressionofadhesionmoleculesmaybealtered,interferingwiththerecruitmentofimmunecellstotheinflammatorysite.InsulintreatmentseemstorecoverthenormalfunctionofimpairedAMs.However,muchresearchisstillneededtocharacterizeAMsandtobetterunderstandtheirroleininflammationandinfection,particularlyindiabeticpatients.Inthisreview,weattempttoexplorerecentlyaccumulatedknowledgeaboutAMfunctionandhowthisfunctionisdeficientinDM.Additionally,AMpolarizationiscomparedbrieflywiththatofTcells,andthismayinterferewithhowimmuneresponseisdriven.ThisreviewdiscusseshowimpairedAMsleadtoanaberrantimmuneresponsethatcontributestoworseninginfectionandautoimmunity,openingupdiscussionforfutureworkinthefield...

【 授权许可】

CC BY