| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Role of the intestinal cytokine microenvironment in shaping the intraepithelial lymphocyte repertoire | |
| 关键词: IL‐; 7; IL‐; 15; IL‐; 2; transforming growth factor‐; β; stem cell factor; | |
| DOI : 10.1189/jlb.3RU1014-465R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
LocalresidentIELsarecomposedofdistinctsubsetsofTcellswithpotentcytolyticandimmunoregulatorycapacities.AsIELsarelocatedwithinthisuniqueinterfacebetweenthecoreofthebodyandtheoutsideenvironment,thespecificdevelopmentandfunctionofintestinalIELsmustbetightlyregulated.Toaccomplishthis,thecytokinemicroenvironmentoftheintestinehasevolvedsophisticatedmechanismsthatmodulatethephenotype,ontogeny,andfunctionofthesecells.Inthisreview,wesummarizetheevidencedemonstratingtheoriginofcertainintestinalcytokines,includingIL‐7,IL‐15,IL‐2,TGF‐β,andSCFanddiscusswhatinfluencesuchcytokinesmayhaveonIELs.Moreover,wereviewdatasuggestingthattheabnormalexpressionofcytokinesthatleadstotheheightenedactivationofIELsmayalsocontributetoimmunopathologicalresponsesorexacerbateinflammatorydiseases,suchasIBDandceliacdisease,orpromotecancerdevelopmentandprogression...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904046973531ZK.pdf | 783KB |  download |
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