Role of the intestinal cytokine microenvironment in shaping the intraepithelial lymphocyte repertoire

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: IL‐;    7;    IL‐;    15;    IL‐;    2;    transforming growth factor‐;    β;    stem cell factor;   

DOI  :  10.1189/jlb.3RU1014-465R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

LocalresidentIELsarecomposedofdistinctsubsetsofTcellswithpotentcytolyticandimmunoregulatorycapacities.AsIELsarelocatedwithinthisuniqueinterfacebetweenthecoreofthebodyandtheoutsideenvironment,thespecificdevelopmentandfunctionofintestinalIELsmustbetightlyregulated.Toaccomplishthis,thecytokinemicroenvironmentoftheintestinehasevolvedsophisticatedmechanismsthatmodulatethephenotype,ontogeny,andfunctionofthesecells.Inthisreview,wesummarizetheevidencedemonstratingtheoriginofcertainintestinalcytokines,includingIL‐7,IL‐15,IL‐2,TGF‐β,andSCFanddiscusswhatinfluencesuchcytokinesmayhaveonIELs.Moreover,wereviewdatasuggestingthattheabnormalexpressionofcytokinesthatleadstotheheightenedactivationofIELsmayalsocontributetoimmunopathologicalresponsesorexacerbateinflammatorydiseases,suchasIBDandceliacdisease,orpromotecancerdevelopmentandprogression...

【 授权许可】

CC BY