The impact of aging on memory T cell phenotype and function in the human bone marrow

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: CD8+CD28–;    T cell;    IL‐;    15;    IL‐;    6;    CD57;    inflamm‐;    aging;    cytomegalovirus infection;   

DOI  :  10.1189/jlb.0611299

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Recently,theBMhasbeenshowntoplayakeyroleinregulatingthesurvivalandfunctionofmemoryTcells.However,theimpactofagingontheseprocesseshasnotyetbeenstudied.WedemonstratethatthenumberofCD4+andCD8+TcellsintheBMismaintainedduringaging.However,thecompositionoftheTcellpoolintheagedBMisalteredwithadeclineofnaïveandanincreaseinTEMcells.IncontrasttothePB,ahighlyactivatedCD8+CD28–Tcellpopulation,whichlacksthelatedifferentiationmarkerCD57,accumulatesintheBMofelderlypersons.IL‐6andIL‐15,whicharebothincreasedintheagedBM,efficientlyinducetheactivation,proliferation,anddifferentiationofCD8+Tcellsinvitro,highlightingaroleofthesecytokinesintheage‐dependentaccumulationofhighlyactivatedCD8+CD28–TcellsintheBM.Yet,theseage‐relatedchangesdonotimpairthemaintenanceofahighnumberofpolyfunctionalmemoryCD4+andCD8+TcellsintheBMofelderlypersons.Insummary,agingleadstotheaccumulationofahighlyactivatedCD8+CD28–TcellpopulationintheBM,whichisdrivenbytheage‐relatedincreaseofIL‐6andIL‐15.Despitethesechanges,theagedBMisarichsourceofpolyfunctionalmemoryTcellsandmaythusrepresentanimportantlineofdefensetofightrecurrentinfectionsinoldage...

【 授权许可】

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