| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Activation of NK cell cytotoxicity by the natural compound 2,3‐butanediol | |
| 关键词: perforin; NKG2D; NCR; resveratrol; | |
| DOI : 10.1189/jlb.0112024 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Thenaturalcompound2,3‐BTDhasdiversephysiologicaleffectsinarangeoforganisms,includingactingasadetoxifyingproductofliveralcoholmetabolisminhumansandamelioratingendotoxin‐inducedacutelunginjuryinrats.Inthisstudy,werevealthat2,3‐BTDenhancesNKcellcytotoxicactivityinhumanpNKcellsandNK92cells.TreatmentofNKcellswith2,3‐BTDincreasedperforinexpressioninadose‐dependentmanner.ThiswasaccompaniedbyelevatedJNKandERK1/2MAPKactivitiesandenhancedexpressionofNKG2D/NCRs,upstreamsignalingmoleculesoftheMAPKpathways.The2,3‐BTDeffectwasinhibitedbypretreatmentwithinhibitorsofJNK(SP)orERK1/2(PD)orbydepletingNKG2D/NCRsorJNK1orERK2withsiRNA.Theseresultsindicatethat2,3‐BTDactivatesNKcellcytotoxicitybyNKG2D/NCRpathwaysandrepresentthefirstreportofthe2,3‐BTDeffectonactivationofinnateimmunitycells...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904045349742ZK.pdf | 1889KB |  download |
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