Interferon at the crossroads of allergy and viral infections

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: atopic asthma;    Th2 cell regulation;    IgE‐;    mediated regulation;    atopic disease;   

DOI  :  10.1189/jlb.3RU0315-099R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

IFN‐α/βwasfirstdescribedasapotentinhibitorofviralreplication,butitisnowappreciatedthatIFNsignalingplaysapleiotropicroleinregulatingperipheralTcellfunctions.Recently,IFN‐α/βwasshowntoblockhumanTh2developmentbysuppressingthetranscriptionfactorGATA3.ThiseffectisconsistentwiththeroleforIFN‐α/βinsuppressingallergicinflammatoryprocessesbyblockinggranulocyteactivationandIL‐4‐mediatedBcellisotypeswitchingtoIgE.WiththeconsiderationofrecentstudiesdemonstratingadefectinIFN‐α/βsecretioninDCsandepithelialcellsfromindividualswithsevereatopicdiseases,thereisanapparentreciprocalnegativeregulatoryloopinatopicindividuals,wherebythelackofIFN‐α/βsecretionbyinnatecellscontributestothedevelopmentofallergicTh2cells.IsitpossibletoovercometheseeventsbytreatingwithIFN‐α/βorbyinducingitssecretioninvivo?Insupportofthisapproach,casestudieshavedocumentedthetherapeuticpotentialofIFN‐α/βintreatingsteroid‐resistantallergicasthmaandotheratopicdiseases.Additionally,individualswithasthmawhoareinfectedwithHCVandrespondtoIFNtherapyshowedareductioninsymptomsandseverityofasthmaattacks.Thesefindingssupportamodel,wherebyallergicandantiviralresponsesareabletocross‐regulateeachother,asIgERcross‐linkingofpDCspreventsIFN‐α/βproductioninresponsetoviralinfection.Theclinicalimportanceofupper‐respiratoryvirusesinthecontextofallergicasthmasupportstheneedtounderstandhowthesepathwaysintersectandtoidentifypotentialtherapeutictargets...

【 授权许可】

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