Anti‐JAM‐C therapy eliminates tumor engraftment in a xenograft model of mantle cell lymphoma

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: B‐;    cell homing;    B‐;    cell proliferation;    mantle cell lymphoma treatment;   

DOI  :  10.1189/jlb.1HI1114-549RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Junctionaladhesionmolecule(JAM)‐CisamemberoftheJAMfamily,expressedbyavarietyofdifferentcelltypes,includinghumanBlymphocytesandsomeB‐celllymphomasubtypes—inparticular,mantlecelllymphoma(MCL).Treatmentwithanti‐JAM‐CpAbsreduceshomingofhumanBcellstolymphoidorgansinaNOD/SCIDmousemodel.Inthepresentstudy,theroleofJAM‐CintheengraftmentofhumanlymphomaBcellsinmicewasinvestigated.Administrationofnovelanti‐JAM‐CmAbsreducedtumorgrowthofJAM‐C+MCLcellsinbonemarrow,spleen,liver,andlymphnodesofmice.Treatmentwithanti‐JAM‐CantibodiessignificantlyreducedtheproliferationofJAM‐C‐expressinglymphomaBcells.Moreover,thebindingofanti‐JAM‐CantibodiesinhibitedthephosphorylationofERK1/2,withoutaffectingothersignalingpathways.TheresultsidentifyforthefirsttimetheintracellularMAPKcascadeastheJAM‐C‐drivensignalingpathwayinJAM‐C+Bcells.TargetingJAM‐CcouldconstituteanewtherapeuticstrategyreducinglymphomaB‐cellproliferationandtheircapacitytoreachsupportivelymphoidmicroenvironments...

【 授权许可】

CC BY