Aggressive disease defined by cytogenetics is associated with cytokine dysregulation in CLL/SLL patients

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: B‐;    cell lymphoma;    Th1;    Th2;    sIL‐;    2Rα;    genetic profile;   

DOI  :  10.1189/jlb.0612301

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

EarlytreatmentofCLL/SLLdoesnotimpactsurvival‐reflectinglimitationsindetectingprogressionearlyandidentifyingasymptomaticpatientslikelytobenefitfromearlytreatment.ImprovedunderstandingofCLL/SLLbiologywouldidentifybetterprognostic/predictivemarkers.ThisstudyattemptstoaddresstheseissuesbydeterminingtherelationshipbetweencytokineaberrationsandpoorclinicaloutcomesinCLL/SLLinthecontextofagenetic–basedprognosticmodel.Fifty‐nineserumcytokines/chemokinesweremeasuredin28untreatedCLL/SLLpatients.PatientswerestratifiedasGRorint/PRusingcytogenetics.ComparisonofCLL/SLLwith28HCsrevealedincreasedexpressionofTh2cytokines(IL‐10,IL‐5,sIL‐2Rα;P≤0.01)anddecreasedlevelsofTh1cytokines(IL‐17,IL‐23,IFN‐γ;P≤0.003).InamultivariateanalysisofGRversusint/PRgroups,differentialexpressionofsIL‐2Rαmaintainedsignificancewithincreasedexpressioninint/PRCLL/SLL.Withmedianfollow‐upof54.3monthsafterdiagnosis,fourpatientsincurreddiseaseprogression,withanIL‐17/sIL‐2Rαmodelpredictingneedfortreatmentinallcases.Insummary,specificcytokinesignaturesareassociatedwithgeneticallydefinedaggressivediseaseandpredictneedfortherapy.Thissuggestsutilityindetectingdiseaseprogressionearly,identifyingthoselikelytoincurasurvivaladvantagewithearlytreatment,anddirectingfuturetherapy...

【 授权许可】

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