Ataxia Telangiectasia-Mutated (ATM)Polymorphisms and Risk of Lung Cancer in a Chinese Population

Frontiers in Public Health

Ajay A. Myneni¹ 

关键词: lung cancer;    ataxia telangiectasia-mutated gene;    DNA repair;    single-nucleotide polymorphisms;    Chinese population;   

DOI  :  10.3389/fpubh.2017.00102

学科分类：卫生学

来源: Frontiers

【 摘 要 】

BackgroundThe ataxia telangiectasia-mutated (ATM) gene has a key role in DNA repair including activation and stabilization of p53, which implicates the importance of ATM polymorphisms in the development of cancer. This study aims to investigate the association of two ATM single-nucleotide polymorphisms (SNPs) with lung cancer, as well as their potential interaction with p53 gene and other known risk factors of lung cancer.

【 授权许可】

CC BY