The anatomy, organisation and development of contralateral callosal projections of the mouse somatosensory cortex:

Brain and Neuroscience Advances

Laura R.Fenlon¹ 

关键词: Corpus callosum;    cortical development;    contralateral targeting;    activity dependence;   

DOI  :  10.1177/2398212817694888

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:Alterations in the development of neuronal connectivity can result in dramatic outcomes for brain function. In the cerebral cortex, most sensorimotor and higher-order functions require coordination between precise regions of both hemispheres through the axons that form the corpus callosum. However, little is known about how callosal axons locate and innervate their contralateral targets.Methods:Here, we use a combination of in utero electroporation, retrograde tracing, sensory deprivation and high-resolution axonal quantification to investigate the development, organisation and activity dependence of callosal axons arising from the primary somatosensory cortex of mice.Results:We show that distinct contralateral projections arise from different neuronal populations and form homotopic and heterotopic circuits. Callosal axons innervate the contralateral hemisphere following a dorsomedial to ventrolateral and region-specific order. Furthermore, we identify two periods of region- and layer-specific ...

【 授权许可】

CC BY