The intestinal microbiome and Alzheimer's disease: A review

Animal Models and Experimental Medicine

Ling Zhang¹  Chuan Qin¹  Hua Zhu¹  Zhuo Li¹ 

[1] Institute of Medical Laboratory Animal Science Chinese Academy of Medical Sciences & Comparative Medical Center Peking Union Medical College Beijing China

关键词: Alzheimer's disease;    blood‐;    brain barrier;    intestinal barrier;    intestinal microbiota;    neuroinflammation;   

DOI  :  10.1002/ame2.12033

学科分类：医学（综合）

来源: Wiley

【 摘 要 】

Alzheimer's disease (AD) is an increasingly common neurodegenerative disease. Since the intestinal microbiome is closely related to nervous system diseases, alterations in the composition of intestinal microbiota could potentially contribute to the pathophysiology of AD. However, how the initial interactions with intestinal microbes alter events later in life, such as during neurodegenerative diseases, is still unclear. This review summarizes what is known about the relationship between the intestinal microbiome and AD.

【 授权许可】

CC BY