Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant:

Innate Immunity

IrenaŽivković¹ 

关键词: Alhydrogel;    antiphospholipid syndrome;    C57BL/6 mice;    fecundity;    natural antibodies;   

DOI  :  10.1177/1753425911407361

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

It has already been shown that tetanus toxoid (TTd) hyper-immunization is a suitable experimental method for creating the animal model of antiphospholipid syndrome (APS) in BALB/c mice. The severity of APS pathology in BALB/c mice mainly correlates to the affinity of anti-β2 glycoprotein I (β2GPI) antibodies. In this study we have investigated reproductive pathology induced in C57BL/6 mice by TTd hyper-immunization using a combination of different pretreatments (complete Freund's adjuvant or glycerol) and adjuvants (alhydrogel or glycerol). A decrease in fecundity was recorded in only C57BL/6 mice immunized with alhydrogel adjuvant, irrespective of the kind of applied pretreatment; it was associated with an increase in abundance of low affinity anti-β2GPI IgG antibodies and Th1 prevalence.

【 授权许可】

CC BY