Распространенность полиморфизма -262С/Т гена каталазы (rs1001179) у русских и бурят Восточной Сибири с эссенциальной артериальной гипертензией

Acta Biomedica Scientifica

Т. А. Баирова¹  О. А. Ершова¹ 

[1] ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»

关键词: окислительный стресс;    артериальная гипертензия;    полиморфизм;    каталаза;    этнос;   

DOI  :  

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Genetic variations that predispose individuals to complex disorders, such as essential hypertension, may be found in gene coding regions, intronic regions or in gene promoter region. Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. In this report we assessed the association between polymorphism -262С/Т in the promoter region of the CAT genes (rs1001179) and essential hypertension in Russian and Buryat populations of Eastern Siberia. In Russian population the frequencies of genotypes were: CC - 58,82 %; CT - 32,35 %; TT - 8,83 %, alleles C - 75 % and T - 25 %. In Buryat population the frequencies of genotypes were: CC - 90 %; CT - 7,5 %; TT - 2,5 %, alleles C - 93,75 % and T - 6,25 %. Statistically significant differences between the frequencies in control and examined groups (х 2= 14,250; р = 0,000) were found in the group of Buryat population.

【 授权许可】

CC BY