Окислительный стресс при гипертермии

Acta Biomedica Scientifica

В. З. Ланкин¹  А. К. Тихазе¹  М. К. Осяева² 

[1] ФГБУ «Российский кардиологический научно-производственный комплекс»;ФГБУ «Российский кардиологический научно-производственный комплекс» Минздрава России

关键词: активные формы кислорода;    свободнорадикальное окисление;    малонилдиальдегид;    каталаза;    глутатионпероксидаза;    супероксидисмутаза;   

DOI  :  10.12737/article_590823a4f0d734.72519988

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Oxidative stress is a risk factor for disease development and cardiovascular system, diabetes, neurodegenerative diseases, etc. The resulting product is thus free radical lipid peroxidation - malondialdehyde (MDA) is atherogenic modification of low density lipoproteins (LDL), so that they acquire the ability to be rapidly accumulated in the cells of the vessel walls, causing pre-aterosklerotic lipoid damages. The aim of this study was to investigate the effect of high temperature (one of the environmental factors) for key operating parameters: the content of secondary products of free radical oxidation polyene lipids - mDa in blood plasma and erythrocyte antioxidant activity of key enzymes. Hyperthermia was triggered in practically healthy volunteers (6 males, 22-46years). The analysis was made using a recording spectrophotometer Hitachi-557 (Japan). The statistical analysis was performed using the non-parametric Wilcoxon-test (Attestat program). MDA levels in the blood plasma, the activity of key antioxidant enzymes in erythrocytes were determined through divided intervals in study participants. A significant increase in MDA content (62 %) and reduction of catalase activity (11 %) and glutathione peroxidase (19 %) were revealed after 30 days in the conditions of hyperthermia test.

【 授权许可】

CC BY