Distribution of genotypes and alleles of the aldosterone-synthase gene in patients with abdominal obesity

Učenye Zapiski Sankt-Peterburgskogo Gosudarstvennogo Medicinskogo Universiteta im. Akad. I.P. Pavlova

T. G. Ivanova¹  O. D. Belyaeva¹  E. I. Baranova¹  E. V. Schlyakhto¹  E. A. Bazhenova¹  T. L. Karonova¹  N. A. Korelskaya²  R. E. Popov²  A. V. Berezina²  O. A. Berkovich²  D. L. Brovin²  S. N. Pchelina² 

[1] Северо-Западный федеральный медицинский исследовательский центр;Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова;

关键词: абдоминальное ожирение;    артериальная гипертензия;    ренин-ангиотензин-альдостероновая система;    полиморфизм;    альдостерон-синтаза;    abdominal obesity;    arterial hypertension;    renin-angiotensin-aldosterone system;    polymorphism;    aldosterone-synthase;   

DOI  :  10.24884/1607-4181-2015-22-2-20-23

来源: DOAJ

【 摘 要 】

We observed 140 patients with abdominal obesity (AO) (IDF, 2005), the residents of St. Petersburg (44.6 ± 0.6 years). Metabolic syndrome (MS) (IDF, 2005) was diagnosed in 49.2% of patients with AO. The most frequent component of MS in patients with AO was arterial hypertension (AH). The distribution of genotypes and -alleles of the aldosterone-synthase gene in patients with AO and in the comparison group (56 subjects without AO, 41.0 ± 1.1 years) didn't differ (p> 0.05). Levels of both systolic and diastolic blood pressure (BP) were higher in carriers of -344T allele of aldosterone-synthase gene. Plasma renin activity, plasma aldosterone and glucose levels, anthropometric parameters, serum blood lipids and carbohydrate metabolism indices in obese patients with different genotypes of aldosterone-synthase gene didn't differ. -344T allele of aldosterone-synthase gene in patients with AO is associated with the increased risk of AH.

【 授权许可】

Unknown