Biodiversity of Borrelia burgdorferi Strains in Tissues of Lyme Disease Patients

PLoS One

Dustin Brisson¹  Ira Schwartz²  Nilofer Baxamusa³  Gary P. Wormser³ 

[1] Biology Department, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America;Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, United States of America;Division of Infectious Diseases of the Department of Medicine, New York Medical College, Valhalla, New York, United States of America

关键词: Borrelia burgdorferi;    Biodiversity;    Blood;    Erythema;    Synovial fluid;    Simpson index;    Lyme disease;    Shannon index;   

DOI  :  10.1371/journal.pone.0022926

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Plant and animal biodiversity are essential to ecosystem health and can provide benefits to humans ranging from aesthetics to maintaining air quality. Although the importance of biodiversity to ecology and conservation biology is obvious, such measures have not been applied to strains of an invasive bacterium found in human tissues during infection. In this study, we compared the strain biodiversity of Borrelia burgdorferi found in tick populations with that found in skin, blood, synovial fluid or cerebrospinal fluid of Lyme disease patients. The biodiversity of B. burgdorferi strains is significantly greater in tick populations than in the skin of patients with erythema migrans. In turn, strains from skin are significantly more diverse than strains at any of the disseminated sites. The cerebrospinal fluid of patients with neurologic Lyme disease harbored the least pathogen biodiversity. These results suggest that human tissues act as niches that can allow entry to or maintain only a subset of the total pathogen population. These data help to explain prior clinical observations on the natural history of B. burgdorferi infection and raise several questions that may help to direct future research to better understand the pathogenesis of this infection.

【 授权许可】

CC BY