Stochastic Resonance Activity Influences Serum Tryptophan Metabolism in Healthy Human Subjects:

International Journal of Tryptophan Research

BertholdKepplinger¹ 

关键词: stochastic resonance therapy;    exercise;    serum;    tryptophan;    L-kynurenine;    kynurenic acid;    Parkinson's disease;    dementia;   

DOI  :  10.4137/IJTR.S7986

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

BackgroundStochastic resonance therapy (SRT) is used for rehabilitation of patients with various neuropsychiatric diseases. An alteration in tryptophan metabolism along the kynurenine pathway has been identified in the central and peripheral nervous systems in patients with neuroinflammatory and neurodegenerative diseases and during the aging process. This study investigated the effect of SRT as an exercise activity on serum tryptophan metabolites in healthy subjects.MethodsSerum L-tryptophan, L-kynurenine, kynurenic acid, and anthranilic acid levels were measured one minute before SRT and at one, 5, 15, 30, and 60 minutes after SRT. We found that SRT affected tryptophan metabolism. Serum levels of L-tryptophan, L-kynurenine, and kynurenic acid were significantly reduced for up to 60 minutes after SRT. Anthranilic acid levels were characterized by a moderate, non significant transient decrease for up to 15 minutes, followed by normalization at 60 minutes. Tryptophan metabolite ratios were moderately alter...

【 授权许可】

CC BY