Fatigue in patients with neuromyelitis optica spectrum disorder and its impact on quality of life

PLoS One

Kwang Ho Lee¹  Pamela Song²  Jin Myoung Seok³  Hye Lim Lee³  Eun Yeon Joo³  Eun Bin Cho⁴  Misong Choi⁵  Ju-Hong Min⁵  Byoung Joon Kim⁵ 

[1] Department of Neurology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Korea;Department of Neurology, Korea University Guro Hospital and Korea University College of Medicine, Seoul, Korea;Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;Department of Neurology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan, Korea;Neuroscience Center, Samsung Medical Center, Seoul, Korea

关键词: Fatigue;    Sleep;    Depression;    Material fatigue;    Sleep disorders;    Lesions;    Central nervous system;    Myelitis;   

DOI  :  10.1371/journal.pone.0177230

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Fatigue is a prevalent symptom and major burden in neuroimmunological diseases. In neuromyelitis optica spectrum disorder (NMOSD), a severe autoimmune central nervous system (CNS) inflammatory disease with autoantibodies reactive to aquaporin-4, there are few reports about fatigue and quality of life (QOL). We aimed to evaluate the severity of fatigue and its relationship with QOL in patients with NMOSD. We prospectively studied patients with NMOSD who were in remission and seropositive for anti-aquaporin-4 antibody, and they were divided into 2 groups based on the presence of fatigue assessed using the Functional Assessment of Chronic Illness Therapy-fatigue score. Sleep quality, depression, pain, and QOL were also evaluated. A total of 35 patients were enrolled (mean age, 46.5 ± 14.1 years; female: male = 29:6), and the median Expanded Disability Status Scale (EDSS) score was 2.0 (range, 0 to 8.0). The patients with fatigue (N = 25, 71.4%) had poorer sleep quality and more severe depression than those without fatigue (p = 0.009 and p = 0.001). Both the physical and mental QOL scores were lower in patients with fatigue than in those without fatigue (p = 0.033 and p = 0.004). Multiple linear regression analyses showed that the degree of fatigue with EDSS score and pain were independent predictors of physical aspects of QOL (B = 0.382, p = 0.001), whereas depression was the only predictor of the mental components of QOL (B = -0.845, p = <0.001). Fatigue is a common symptom and an important predictor of QOL in patients with NMOSD.

【 授权许可】

CC BY