Fatigue, mood, and sleep, during intraperitoneal chemotherapy: a pilot case control study

International Journal of Psychological Research

Anna Barata¹  Robert Wenham²  Paul Jacobsen²  Heather Jim² 

[1] Hematology Service, Hospital de la Santa Creu i Sant Pau, Mas Casanova 90, 08004 Barcelona. Universitat Autonoma de Barcelona;Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612 USA;

关键词: Ovarian Neoplasm;    Intraperitoneal Infusions;    Chemotherapy;    Fatigue;    Depression;    Sleep;   

DOI  :  10.21500/20112084.694

来源: DOAJ

【 摘 要 】

The goal of this pilot study was to compare longitudinal changes in fatigue, depressive symptoms, sleep, and activity in women (n = 10) undergoing intraperitoneal (IP) versus intravenous (IV) chemotherapy for ovarian cancer. Fatigue and depressive symptoms were assessed via self –report and sleep and activity via wrist actigraphy in the week before and the week after the first infusion. Both groups demonstrated increases in fatigue and depressive symptoms, declines in sleep, reduced daytime activity, and decreased rhythmicity of sleep/activity patterns (p<.05). Effect sizes for within-group comparisons tended to be higher in the IP group (ds = -.15 to -8.03) than the IV group (ds = .12 to 1.40). Between-group comparisons revealed that IP patients demonstrated trends towards more severe symptoms post-chemotherapy in nearly all outcomes (p<.10). These results suggest that IP patients experience large increases in fatigue, depressive symptoms, and alterations in sleep and activity relative to IV patients.

【 授权许可】

Unknown