Supplementation of beef extract improves chemotherapy-induced fatigue and toxic effects in mice

Journal of Functional Foods

Shao-Wen Hung¹  Guo-Chi Lee²  Chia-Chi Chen³  Tsung-Hsien Hsu⁴  Chean-Ping Wu⁴  Chun-Yun Wu⁴  Chien-Chao Chiu⁴  Hsin-Tai Hong⁴  Jyh-Shiun Lin⁴ 

[1] Department of Animal Science, National Chiayi University, Chiayi 600, Taiwan;Department of Animal Science, National Chiayi University, Chiayi 600, Taiwan;Department of Science and Technology, Council of Agriculture Executive Yuan, Taipei 100, Taiwan;Division of Animal Industry, Animal Technology Laboratories, Agricultural Technology Research Institute, Miaoli 350, Taiwan;

关键词: Beef extract;    Chemotherapy;    Fatigue;    Antioxidant enzymes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Physiological fatigue and toxic effects are commonly associated with chemotherapy. Beef extract (BE) is a nutritional supplement obtained by cooking beef. The present study examined the effects of several BE concentrations on 5-fluorouracil (5-FU)-induced fatigue and toxic effects in mice. Results showed BE supplementation ameliorated 5-FU-induced body and organ weight loss. All BE + 5-FU groups demonstrated increased grip strength (135.3–163.2 g), endurance time (567.3–911.3 s), and movement distance (23623–31225 cm) when compared with the 5-FU group (97.6 g, 265.2 s, and 13916 cm). Hepatic and muscular (0.76 and 1.06 mg/g) glycogen levels were maintained in the BE-3x + 5-FU group when compared with the 5-FU group (0.44 and 0.58 mg/g). Moreover, catalase (liver and muscle) and glutathione peroxidase (liver) activities were enhanced. The serum alanine aminotransferase, aspartate aminotransferase, and histopathological changes were ameliorated in the BE-2x + 5-FU and BE-3x + 5-FU groups. BE supplementation could provide a novel strategy for managing 5-FU-induced fatigue and toxic effects.

【 授权许可】

Unknown