A new piece of an old puzzle: lack of association between C-Rel (rs13031237-rs842647) single nucleotide polymorphisms and non-segmental vitiligo

Biomedical Dermatology

Alshymaa A. Ahmed¹  Eman Salah³ 

[1]Andrology department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

[2]Clinical Pathology department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

[3]Dermatology, Venereology &

关键词: Melanocytes;    Depigmentation;    Autoimmune;    T-regulatory cells;    FOXP3;   

DOI  :  10.1186/s41702-018-0027-6

学科分类：皮肤病学

来源: Springer

【 摘 要 】

The exact pathogenesis of vitiligo is still unclear; however, studies mostly support autoimmune mechanisms including altered T-regulatory cells and FOXP3. C-Rel is a NF-κB family member affecting the normal development of FOXP3+ regulatory T cells. The aim was to examine the association between 2 C-Rel gene polymorphisms (rs13031237 and rs842647) and non-segmental vitiligo patients. Genomic DNA was isolated from blood samples of 100 patients plus 100 controls for genotyping using restriction fragment length polymorphism and DNA sequencing analyses. Statistical analysis was performed using SPSS program version 21 (IBM Corp., Chicago, IL, USA). The genotype frequencies did not differ significantly from non-segmental vitiligo patients to controls for both alleles. C-Rel (rs13031237 and rs842647) polymorphisms are not associated with increased risk for non-segmental vitiligo. We recommend testing additional mutations in vitiligo patients from different populations to unravel Rel aspects among different autoimmune disorders.

【 授权许可】

CC BY