Age-related autoimmunity

BMC Medicine

Elias Toubi¹  Aharon Kessel¹  Tharwat Haj¹  Zahava Vadasz¹ 

[1]Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Golomb Street 47, Haifa, 31048, Israel

关键词: T-regulatory cells;    Sepsis;    Cancer;    Autoimmunity;    Aging;   

Others  :  857112
DOI  :  10.1186/1741-7015-11-94

 received in 2013-02-15, accepted in 2013-02-15,  发布年份 2013

【 摘 要 】

Older persons have higher autoimmunity but a lower prevalence of autoimmune diseases. A possible explanation for this is the expansion of many protective regulatory mechanisms highly characteristic in the elderly. Of note is the higher production of peripheral T-regulatory cells.

The frequent development of autoimmunity in the elderly was suggested to take place in part due to the selection of T cells with increased affinity to self-antigens or to latent viruses. These cells were shown to have a greater ability to be pro-inflammatory, thereby amplifying autoimmunity. During aging, thymic T-regulatory cell output decreases in association with the loss of thymic capacity to generate new T cells. However, to balance the above mentioned autoimmunity and prevent the development of autoimmune diseases, there is an age-related increase in peripheral CD4+ CD25highFoxP3+ T-regulatory cells. It remains unclear whether this is an age-related immune dysfunction or a defense response. Whatever the reason, the expansion of T-regulatory cells requires payment in terms of an increased incidence of cancer and higher susceptibility to infections.

【 授权许可】

   
2013 Vadasz et al.; licensee BioMed Central Ltd.

【 图 表 】

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