Association between Vitamin D Insufficiency and Elevated Serum Uric Acid among Middle-Aged and Elderly Chinese Han Women

PLoS One

Qiu Zhang¹  Xiangqin Chao¹  Yonghong Zhang²  Hongmei Li²  Hao Peng²  Chao Li³ 

[1] Center for Disease Prevention and Control of Jinchang District, Suzhou, China;Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, China;Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China

关键词: Vitamin D;    Uric acid;    Diabetes mellitus;    Hypertension;    Chinese people;    Han Chinese people;    Alcohol consumption;    Smoking habits;   

DOI  :  10.1371/journal.pone.0061159

学科分类：医学（综合）

来源: Public Library of Science

【 摘 要 】

Background Association between vitamin D insufficiency and hyperuricemia has not been reported so far. We aimed to study the association of vitamin D insufficiency with elevated serum uric acid among middle-aged and elderly Chinese Han women. Methods We collected data from participants residing in Jinchang district of Suzhou from January to May, 2010. Serum uric acid, 25-hydroxy vitamin D and other traditional biomarkers including fasting plasma glucose and blood lipids were determined in 1726 women aged above 30 years. Association between vitamin D insufficiency and elevated uric acid was analyzed in premenopausal and postmenopausal women, respectively. Results Among postmenopausal women, 25-hydroxy vitamin D level of participants with elevated uric acid was lower than that of those with normal uric acid (median [interquartile range]: 35[28–57] vs 40[32–58], µg/L; P = 0.006). Elevated uric acid was more prevalent in participants with vitamin D insufficiency compared to those without vitamin D insufficiency (16.50% vs 8.08%; P<0.001). Association between vitamin D insufficiency and elevated uric acid was not significant among premenopausal women. However, participants with vitamin D insufficiency were more likely to have elevated uric acid compared with those without vitamin D insufficiency among postmenopausal women (OR, 95% CI: 2.38, 1.47–3.87). Moreover, after excluding individuals with diabetes and/or hypertension, the association of vitamin D insufficiency with elevated uric acid was still significant (OR, 95% CI: 2.48, 1.17–5.44). Conclusions Vitamin D insufficiency was significantly associated with elevated uric acid among postmenopausal Chinese Han women. This study suggested that a clinical trial should be conducted to confirm the association of vitamin D insufficiency with hyperuricemia.

【 授权许可】

CC BY