Urate Transporter Gene SLC22A12 Polymorphisms Associated with Obesity and Metabolic Syndrome in Caucasians with Hypertension

Kidney and Blood Pressure Research

Johnson R.J.³  Gong Y.⁴  Langaee T.⁴  Turner S.T.¹  Gums J.G.⁴  Shafiu M.⁴  Johnson J.A.⁴  Chapman A.B.² 

[1] Division of Nephrology, Emory University School of Medicine, Atlanta, Ga., USA$$;Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colo., $$;College of Pharmacy and Center for Pharmacogenomics and $$

关键词: Hypertension;    Metabolic syndrome;    Obesity;    SLC22A12 polymorphisms;    URAT1;    Uric acid;   

DOI  :  10.1159/000337370

来源: S Karger AG

【 摘 要 】

Background/Aims: Hyperuricemia is associated with obesity and the metabolic syndrome. URAT1 is a urate transporter, and we tested the association of URAT1 transporter gene (SLC22A12) polymorphisms with obesity and the metabolic syndrome in hypertensive subjects. Methods: Patients with essential hypertension (n = 414) from a randomized controlled study were genotyped for SLC22A12 SNPs rs11602903, rs505802 and rs11231825. Results: In Caucasians, SLC22A12 SNPs were associated with the body mass index (BMI). rs11602903 was associated with BMI (p < 0.0001), waist circumference (p = 0.003), HDL cholesterol (p = 0.018) and the metabolic syndrome (p = 0.033), and accounted for 7% of the variation of BMI in Caucasians. In African Americans, SLC22A12 SNP rs11602903 was not associated with BMI, waist circumference, HDL cholesterol or triglycerides. Conclusion: The URAT1 gene SLC22A12 polymorphism may play a role in obesity and the metabolic syndrome in Caucasian hypertensive subjects.

【 授权许可】

Unknown