期刊论文详细信息
卷:101
Fish intake and risk of chronic obstructive pulmonary disease in 2 large US cohorts
Varraso, Raphaelle ; Barr, R. Graham ; Willett, Walter C. ; Speizer, Frank E. ; Camargo, Carlos A., Jr.
INSERM
关键词: diet;    epidemiology;    respiratory diseases;    fish;    dietary patterns;   
DOI  :  10.3945/ajcn.114.094516
学科分类:食品科学和技术
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【 摘 要 】

Background: Despite mechanistic data that linked fish and omega-3 (n-3) PUFAs with lower risk of chronic obstructive pulmonary disease (COPD), epidemiologic data remain scarce. Fish and n-3 PUFAs are an important component of the prudent dietary pattern that is thought to be protective in the onset of COPD. Objective: We examined the role of fish and PUPA intakes on risk of developing COPD while taking into account the overall dietary pattern. Design: We investigated the objective in 120,175 women and men from the Nurses' Health Study and Health Professionals Follow-Up Study. Over the study period (1984-2000), there were 889 cases of newly diagnosed COPD. Cumulative average intakes of fish, eicosapentaenoic acid, docosahexaenoic acid, n-3 PUFAs, n-6 PUFAs, and the n-3:n-6 ratio were calculated from repeated food-frequency questionnaires. Because fish is a food group included in the prudent pattern, we derived a new prudent pattern without the contribution from fish, and we termed this pattern the "modified prudent" pattern. We performed multivariable Cox proportional hazards models. Results: Before the dietary pattern was taken into account, and with 14 factors controlled for, we showed that more-frequent fish intake (>= 4 servings/wk) was inversely associated with risk of COPD [adjusted pooled HR for the highest intake compared with the lowest intake (<1 serving/wk): 0.71; 95% CI: 0.54, 0.94]. After additional adjustment for the dietary pattern (modified prudent and Western patterns), the association was NS (0.84; 95% CI: 0.63, 1.13). No Significant associations were shown between PUPA intakes and risk of COPD. Conclusion: Although COPD-prevention efforts should continue to focus on smoking cessation, these prospective findings support the importance of promoting a healthy diet in multi-interventional programs to prevent COPD instead of focusing on changes in an isolated food or nutrient.

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