BMI status influences the response of insulin sensitivity to diacylglycerol oil in Chinese type 2 diabetic patients

卷:24

Zheng, Ju-Sheng ; Wang, Ling ; Lin, Mei ; Yang, Hong ; Li, Duo

关键词: BMI;    diacylglycerol;    insulin sensitivity;    randomized controlled trial;    type 2 diabetes;   

DOI  :  10.6133/apjcn.2015.24.1.01

学科分类：食品科学和技术

【 摘 要 】

Present study was a post-hoc analysis and aimed to examine the influence of adiposity status on the response of insulin sensitivity to diacylglycerol (DAG) oil in type 2 diabetic patients. A total of 127 type 2 diabetic patients were recruited into a randomized double-blind controlled parallel trial in Hangzhou, China. Subjects were allocated to consume the same amount (25 mL/d) of DAG (n=66) or triacylglycerol (TAG) oil (n=61) with similar fatty acid compositions for 120 days. Marginally significant interaction was observed between BMI status (overweight versus normal weight) and test oils for fasting insulin (p-interaction=0.046) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) (p-interaction=0.059). For normal weight subjects (BMI <= 25), DAG group showed significant decrease of fasting insulin (-2.0, 95% CI: -3.90, -0.10; p=0.036) and HOMA-IR (-0.69, 95% CI: -1.36, -0.03; p=0.015), but not in the TAG group. No significant change of either trait in DAG or TAG group was observed for overweight subjects (BMI>25). In summary, the effect of DAG oil on insulin sensitivity in type 2 diabetic patients is influenced by the baseline BMI status. Type 2 diabetic patients may benefit from DAG oil in terms of insulin sensitivity improvement, however only when they are in normal body weight range.