Reduced genetic influence on childhood obesity in small for gestational age children

BMC Medical Genetics

Lynnette R Ferguson²  Edwin A Mitchell³  Karen E Waldie³  Clare R Wall⁴  John M D Thompson³  Wen Jiun Lam²  Angharad R Morgan²  Rinki Murphy¹  Dug Yeo Han² 

[1] Department of Medicine, FM&HS, The University of Auckland, Auckland, New Zealand;Nutrigenomics New Zealand, Auckland, New Zealand;Department of Paediatrics, FM&HS, The University of Auckland, Auckland, New Zealand;Discipline of Nutrition, FM&HS, The University of Auckland, Auckland, New Zealand

关键词: SGA children;    AGA children;    Childhood obesity;    BMI;   

Others  :  1177745
DOI  :  10.1186/1471-2350-14-10

 received in 2012-06-12, accepted in 2013-01-18,  发布年份 2013

【 摘 要 】

Background

Children born small-for-gestational-age (SGA) are at increased risk of developing obesity and metabolic diseases later in life, a risk which is magnified if followed by accelerated postnatal growth. We investigated whether common gene variants associated with adult obesity were associated with increased postnatal growth, as measured by BMI z-score, in children born SGA and appropriate for gestational age (AGA) in the Auckland Birthweight Collaborative.

Methods

A total of 37 candidate SNPs were genotyped on 547 European children (228 SGA and 319 AGA). Repeated measures of BMI (z-score) were used for assessing obesity status, and results were corrected for multiple testing using the false discovery rate.

Results

SGA children had a lower BMI z-score than non-SGA children at assessment age 3.5, 7 and 11 years. We confirmed 27 variants within 14 obesity risk genes to be individually associated with increasing early childhood BMI, predominantly in those born AGA.

Conclusions

Genetic risk variants are less important in influencing early childhood BMI in those born SGA than in those born AGA, suggesting that non-genetic or environmental factors may be more important in influencing childhood BMI in those born SGA.

【 授权许可】

   
2013 Han et al.; licensee BioMed Central Ltd.

【 图 表 】

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